The number of people killed in China by the coronavirus has risen to 80, with almost 3,000 confirmed ill.
The national new year holiday has been extended by three days to Sunday, in an attempt to contain the spread.
On Monday, Chinese Premier Li Keqiang visited Wuhan, the capital of Hubei province and centre of the outbreak.
The number of deaths in Hubei province has climbed from 56 to 76, with four deaths elsewhere.
Wuhan is in lockdown and several other cities have imposed travel bans.
The overall number of confirmed cases in China is 2,744. State media say more than 300 are critically ill.
At least 42 cases have been confirmed abroad, including in Thailand, the United States, and Australia.
There have been no deaths outside China.
The coronavirus causes severe acute respiratory infection and there is no specific cure or vaccine.
Most deaths involve elderly people or those with pre-existing respiratory problems.
Travel from the city, home to 11 million people, has been severely restricted and non-essential vehicles have been banned from the roads.
At the Hubei border, workers are checking people's temperatures before allowing them into the province.
The emergency has overwhelmed Wuhan's hospitals. More than half a million medical staff have joined prevention, control and treatment operations in the province.
On Monday, Chinese Premier Li inspected the ongoing efforts, and spoke to patients and medical staff, a government statement said.
Two new makeshift hospitals are being built in the city and factories are rushing to produce masks and protective clothing.
The city's mayor Zhou Xianwang said the number of cases would continue to rise, and warned that around five million new year travellers left the city before the lockdown.
New year celebrations were scaled back and four major cities - Beijing, Shanghai, Xian and Tianjin - have banned long-distance busses.
Extending the new year holiday until Sunday means schools and official institutions will remain closed for the rest of this week.
Beijing has closed the Forbidden City for tourists, as well as a section of the Great Wall.
In Guangdong province, several cities have made face masks mandatory in public. Both Disney parks in Hong Kong and Shanghai have closed.
Hong Kong, which has eight confirmed cases, has declared a city-wide emergency, with schools closed until 17 February.
Over the weekend, Chinese officials warned the virus was able to spread during its incubation period, making it harder to contain the illness.
In humans, the incubation period - during which a person has the disease, but no symptoms - ranges from between one and 14 days, officials believe.
According to the World Health Organization and national authorities, there have been at least 42 confirmed cases outside China.
Almost all had recently been to Wuhan.
The virus is thought to have emerged from illegally-traded wildlife at the Huanan seafood market in Wuhan.
Authorities have since temporarily banned the sale of all wildlife in China.
The virus itself is a new, or "novel" coronavirus - a family that normally affects animals.
One human variant causes the common cold - but another variant, Sars, killed hundreds in a major outbreak in 2003.
Police and officials in the impact zone in Hubei and Henan provinces are now very keen to move us on wherever we arrive.
They don't seem to mind where we go - as long as we leave their towns.
We explain that the world wants to see the important, tiring work they're doing to combat the virus. But they're not interested.
It could be that they're worried that our presence might imply to some that their patch is not handling this emergency well enough.
One police officer at the entrance to a small town in Henan said to me: "We don't have a problem here any more so there's no need for you to be here."
He said this at a checking station as cars were being pulled up behind him. Medical staff covered head to toe in protective clothing were then screening every passenger.
They also checked the inside of all vehicles. I'm not sure what they were looking for - but it certainly didn't look like business as usual.
Russia's unmanned Luna-25 spacecraft has crashed into the Moon after spinning out of control, officials say.
Donald Trump has confirmed that he will not take part in Republican presidential debates with his rivals in the race for the White House.