EU drug regulator: Unusual blood clot is 'very rare AstraZeneca side effect'
8-04-2021, 08:25

Font size: [ A+ ] / [ A- ]

 

The EU's medicines regulator says unusual blood clots should be listed as a very rare side effect of the AstraZeneca vaccine for Covid-19.

After a study looking at 86 European cases, the European Medicines Agency (EMA) concluded the benefits of the vaccine outweighed the risk.

The report reflected data on 25 million Europeans administered with the jab.

The EMA could not list specific risk factors such as age or gender, but most blood clot cases were women under 60.

Separately, the UK's vaccine advisory body said that under-30s there were to be offered an alternative jab to AstraZeneca due to the blood clots issue. Some 79 people had suffered rare blood clots after vaccination by the end of March in the UK - 19 of whom had died.

And the World Health Organization's advisory vaccine safety panel said on Wednesday that although a blood clot link was "plausible" it was "not confirmed" and the cases were "very rare" among 200 million people vaccinated with AstraZeneca globally.

More than 132 million Covid-19 infections have been recorded across the world, along with more than 2.8 million deaths, according to Johns Hopkins University research.

 

 

What did the EMA find?

 

 

There were two main elements to its report - the link with blood clots and how this could affect vaccination programmes.

The EMA had concluded there was a "possibility of very rare cases of blood clots combined with low levels of blood platelets occurring within two weeks of vaccination" with the AstraZeneca jab.

Most of the 86 cases studied in the European Economic Area (the EU, Iceland, Norway and Liechtenstein) up to 22 March were in women under 60. Eighteen were fatal.

But EMA executive director Emer Cooke said there was no available evidence of "specific risk factors such as age, gender, or previous medical history of clotting disorders".

On the safety side, she said: "Our safety committee... has confirmed that the benefits of the AstraZeneca vaccine in preventing Covid-19 overall outweigh the risks of side effects."

Ms Cooke added: "This vaccine has proven to be highly effective - it prevents severe disease and hospitalisation, and it is saving lives."

AstraZeneca has said its studies have found no causal link with blood clots.

Ms Cooke said that one "plausible explanation for these rare side effects is an immune response to the vaccine".

The condition is similar to one seen in people who have been treated with the drug heparin, a blood thinner used to prevent the formation of clots.

In some cases there has been a potentially dangerous immune-driven adverse reaction to the drug, leading to a condition called heparin-induced thrombocytopenia, or HIT.

 

 

What action could EU nations take now?

 

 

Although the EMA evaluates and supervises medicine use for all of the EU, including drug approval, this does not mean there has been unity on tackling Covid-19.

After a virtual meeting of EU health ministers on Wednesday to discuss the EMA findings, European Commissioner for Health Stella Kyriakides said in a statement: "Our decisions should now be based on the scientific work of EMA, and a rigorous, continuous assessment of risks and benefits.

"I have today called on Health Ministers to follow a coordinated approach across Europe to improve public confidence."

But earlier Belgium announced it would restrict AstraZeneca to those aged 56 and above and then Italy said it was recommending reserving it for the over 60s. But Italy also said there was no evidence to stop people having a second dose of AstraZeneca.

Spain later said that it was restricting AstraZeneca to those between 60 and 64.

Countries within the bloc have diverged widely on vaccination campaigns and on the use of the AstraZeneca jab.

France recommends that AstraZeneca vaccinations be given only to those aged 55 or over. In Germany it is over 60, plus high-priority groups. Norway, not an EU member, and Denmark have a full suspension.

Germany also says its under-60s who have received an AstraZeneca first dose should now get a different vaccine for their second.

France, Finland and Norway could consider similar moves.

Studies are still being done on the effectiveness of mixed vaccines.

The EU has ordered 400 million doses of the Oxford-AstraZeneca vaccine but has been locked in a dispute over supply, saying AstraZeneca has not met its obligations.

Nevertheless, some EU nations have not used the AstraZeneca vaccines that have been supplied, with a drop in public confidence being blamed.

 

BBC

Comments: 123
#3   Donnell
      
In a landmark research, Booth and his colleagues appeared at the
physical, emotional, and sexual well-being of nearly four,four hundred men whose testosterone levels fell throughout the traditional spectrum.

They discovered that the healthiest males have been extra milquetoasts than mansters, with T levels in the lower midrange.
Conversely, males whose T bordered on 1,000 ng/dl endangered their lives more
usually. Nevertheless, it is important to note that testosterone is solely one issue among many
that influence societal norms and gender roles.

However, female-pattern hair loss usually causes hair thinning over the whole scalp.

Testosterone is hailed as an important hormone in your physique for an excellent purpose – it’s important to your wellbeing.
We appreciate not every ounce of stress in your life may be taken away.
Nonetheless, we encourage you to take time
to loosen up, unwind, and think about How To
use steroids safely for bodybuilding
much stress you probably can reduce ties with.
Living a health-promoting life-style works to create the best surroundings for testosterone to thrive.

Fortuitously, the Atkins food plan reduces dangerous ldl cholesterol and triglycerides
whereas additionally rising HDL ranges. Gluten intolerance is described because the
digestive antagonistic effects sufferers experience after
ingesting gluten-rich foods, similar to wheat, rice, and barley.
If you’re thinking about getting tested for
hormone imbalances, you'll be able to go to our web site gettested.co.in to choose the
check you need. Vitamin D is a crucial compound that mediates several physiological capabilities in the body.

In males, it’s diagnosed when levels fall beneath 300 nanograms per deciliter (ng/dL).

This, in flip, makes their male hormones, also called androgens, somewhat greater.
In Accordance to the AUA, low testosterone for grownup males who don’t
have obesity is beneath 300 ng/dL. Nonetheless, laboratories could
report ranges right down to 264 ng/dL as inside the regular
range. In people who find themselves premenopausal, testosterone is made mainly in the
ovaries.
The industrial testosterone merchandise on the market
are intended and FDA-approved for males solely. One of the most persistent myths around TRT is that it makes men overly
aggressive or "unnatural." The reality? Cortisol, the hormone that your body releases each time you’re uncovered to stress,
has an inhibitory effect on testosterone synthesis.
It Is essential to notice that while these pure methods may help optimize testosterone levels, they will not be suitable for everyone.
If you may have issues about your testosterone levels or
some other hormonal imbalances, it is best to
seek the guidance of with a healthcare skilled who can present personalized advice and guidance.
Conditions similar to hypogonadism, which is characterised by
inadequate testosterone production, can significantly influence testosterone ranges.
Other situations, such as weight problems, diabetes,
and sure hormonal disorders, can even have an result on testosterone production. In different words, men with larger testosterone levels at the start of the research had a lower fee of decrease—or no lower
at all—as they aged. This highlights the importance of maintaining wholesome testosterone ranges at any age,
particularly earlier than old age.
Hormone remedy, or particularly testosterone remedy, is a potential answer for
regulating testosterone ranges in the course of the menstrual cycle.
Testosterone remedy entails the administration of exogenous testosterone to complement the physique's
natural manufacturing. This may be done through varied methods, similar to
topical gels, patches, injections, or pellets.

Though research is proscribed, there could be proof that fish oil supplementation might enhance testosterone production by supporting testicular health.
More research are wanted to research the direct influence of fish oil on testosterone ranges.

Androgen receptors occur in many alternative vertebrate physique
system tissues, and both males and females reply equally to related levels.
Greatly differing amounts of testosterone prenatally, at puberty,
and all through life account for a share of biological variations between males and females.

Testosterone injections supply a potential answer,
offering a constant, steady degree of this hormone to combat pure decline and
help alleviate symptoms.
As you might know, some regions in the world are more susceptible to
sure allergens than others. Some individuals take this even additional
and reduce sugar intake to 1-5% of their daily calories.
The new ratio will stimulate the liver to activate the
"fat-burning" metabolic pathways to make use of triglycerides (i.e.
fatty acids) for power.
22 May 2025 08:14
#2   Quinton
      
In summary, excessive testosterone ranges in men can lead to a spread of signs that
may impact total well-being. It is important for individuals experiencing these symptoms to consult with a
healthcare provider to determine the underlying cause and appropriate remedy options.

Excessive testosterone ranges in people may be influenced by a
big selection of components, ranging from genetic predisposition to life-style
elements.
In this blog post, we’ll delve into the signs of excessive testosterone, also referred to
as hyperandrogenism, and what they imply for
men’s well being. In addition to that, there are prescription medicines that you could take that’ll decrease T ranges.
Extra specifically, the sebum will clog your hair follicles, together
with useless skin cells, and other particles.
From there, there’s a excessive probability that it’ll turn out to be infected and switch into zits.

Tips range, as do elements like age or medicine
use, however a standard level for an adult male sometimes ranges between 450
and 600 nanograms (ng) per deciliter (dL).

Levels at 300 ng/dL or much less are thought-about low and
above 1,000 ng/dL is high. For adverse results, excessive testosterone levels
incessantly make men really feel extra irritable, more anxious, and extra
likely to develop melancholy. Many men with abnormally high testosterone—naturally or via the usage of Steroids Online Review (Https://Jobcopeu.Com/Employer/Average-Free-Testosterone-Levels-By-Age/)—report elevated
frequency of violent ideas, goals, and a common rise in aggressiveness.
On the plus aspect, men with excessive testosterone levels may even probably feel
extra energetic and extra alert throughout the day, and sometimes have
enhanced libido. They’re also typically extra bodily capable and able to construct and keep more muscle than men with normal or low ranges of testosterone.

…And that’s basically why girls don’t have big Adam’s apple’s, they don’t have sufficient androgens to
have one. Their doctor can then work with them to create an appropriate remedy plan. Testosterone is
crucial for well being, however an extreme quantity of could improve the chance of well being problems,
similar to an enlarged prostate gland. Treating your symptoms could also be an easy preliminary way to
cut back the results of excessive T on your body.
Eliminating any external supply of high T ranges is often the primary line of therapy for high T caused by treatment or steroid use.
Nevertheless, researchers also noted no important change within the ratio between free testosterone, complete
testosterone, and cortisol, a kind of stress hormone.

These small stressors accumulate, overwork our HPA axis, and erode our capacity
for pleasure and connection.
Testosterone, a hormone that acts as a chemical messenger, is
important for each men and women. Too much or too little testosterone can result in unwelcome symptoms and may be associated to well being
conditions that require care. TRT raises testosterone ranges
but it also lowers sperm production by decreasing levels
of another hormone, called follicle-stimulating hormone (FSH), which
is important to produce sperm.
If you think your testosterone levels are
changing, it’s best to get examined by a professional.

It’s important to seek the guidance of with a healthcare supplier to determine the specific trigger in your case.
Sure, it's attainable to lower excessive testosterone ranges naturally through
numerous way of life modifications.
In some cases, hormone remedy or medication could also be
essential to lower testosterone ranges and
scale back well being risks. In conclusion, excessive testosterone ranges can have
numerous results on well being, starting from specific circumstances such as PCOS and precocious puberty to potential psychological consequences.
It is important to acknowledge the function of testosterone in overall health, but it's equally
important to grasp that different elements also contribute to the manifestation of
these circumstances. When ladies have high testosterone levels, it can lead to noticeable
modifications of their bodily look. Moreover, excessive testosterone ranges can impact mood regulation in both men and women.
Understanding and managing high testosterone is essential for maintaining general well being and well-being.
Figuring Out the best treatment choices,
together with hormone therapy, can significantly improve signs and quality
of life. An enlarged prostate can be a direct result
of excessive testosterone levels. Symptoms include issue urinating or frequent urges to urinate, particularly
at night time. Thus, levels that surpass this threshold are sometimes flagged as high.
20 May 2025 05:47
#1   Seymour
      
If this is the case, working with the proper provider may help you get again right into a wholesome vary.

Testosterone remedy could make sense for girls who've low testosterone levels and signs that may be because of testosterone deficiency.
Nonetheless, the knowledge and effectiveness of testosterone remedy to
improve sexual function or cognitive function among postmenopausal ladies is unclear.
Increased testosterone ranges, especially in men with beforehand low ranges, could expertise several
advantages.
To find out that I had chronically low testosterone, that it
was principally a chemical downside, that was huge.
I Googled "hormone replacement remedy clinic" and went to the primary place
that popped up. They’ll provide you with no matter you need so long as it is loosely
associated to the signs you tell them you may have. She’s in all
probability in her late forties, thin as a rail with massive pretend boobs,
pouty injected lips, spray-tanned skin, and tons of make-up.
She rolls up on an everyday basis in an Escalade
wearing every kind of knickknack. Whatever the bare minimal qualification is to
prescribe testosterone, that’s what she has.

As a vital male intercourse hormone, testosterone has several well being advantages.
For individuals with a vulva, excessive testosterone levels can result in an irregular menstrual
cycle, elevated muscle mass, or an enlarged clitoris.

For example, athletes and bodybuilders typically use anabolic steroids to improve athletic performance
and construct muscle mass.
This is why it’s so necessary to have a thorough analysis earlier than leaping
into remedy. TRT injection frequency and delivery method matter greater than most men notice.
If your supplier isn’t customizing your dose, supply
methodology, and frequency based on your labs, signs, and life-style, that’s a purple flag.

A dialed-in protocol should be customized, monitored carefully, and adjusted over time.

Understanding your present levels is crucial for taking steps toward rebalancing your
hormones and mitigating any antagonistic results. While optimum testosterone ranges contribute considerably to a man’s health, crossing the threshold into extreme quantities can introduce a bunch of potential dangers.
These elevated levels, whether or not because of natural variation, lifestyle components,
or supplementation, can impact both bodily and psychological well-being in sudden methods.
Hassle sleeping or staying asleep could be linked to elevated testosterone
ranges. Quality sleep is significant for total health, so disturbances in your sleep sample
are a sign that something may have attention. It’s elementary for male development and health, affecting everything from physical look to mood.

Careful monitoring of hematocrit levels and staying forward of
any problematic ranges is a serious focus of excellent
TRT. In truth, the vast majority of studies following PSA (Prostate Specific Antigen) show
that it doesn't enhance significantly with testosterone therapy.
Finding that correct dosage is key—while low testosterone can have a quantity
of unpleasant signs, too much testosterone can also have side effects.
Excessive testosterone can cause modifications in temper, body hair, and extra.

In doing so, you presumably can decrease the risks of blood clots, coronary heart attack,
stroke, mood swings, and zits. Excessive blood
cell depend is one of the largest things to look out for
throughout testosterone remedy. TCT helped me find the right level
of testosterone, and I know they will do the same
for you. The link between the prostate and testosterone is a highly debated subject within the medical world.

Excessive testosterone might result in mood disturbances such as
irritability, aggression, and hassle sleeping.
In addition, it could impair judgment and decision-making skills.
Abnormally high testosterone levels could sometimes worsen mental health issues like despair and
can also contribute to a sense of restlessness.

Males with excessive testosterone levels could expertise a rise in energy ranges.


As stunning as it might be, ladies can additionally be bothered
by symptoms of testosterone deficiency. For example, problem with operate of pituitary gland or adrenal glands might result in reduced testosterone manufacturing.
Affected ladies might expertise low libido, decreased bone power, poor focus or
depression. Part of this can be because of the problem defining "regular" testosterone levels and "regular" conduct.
In addition, what may appear to be a symptom of testosterone excess
(see below) may actually be unrelated to this hormone.


References:


Legal Anabolics
18 May 2025 15:34
Add Comments

Name:*
E-Mail:
  Geo Keyboard  
 

Dear reader, guardian.ge welcomes your comments. Please express your views on topic and be respectful of others.

bold italic underline strike | align left centered align right | Ensert smilies insert linkInsert protected URL Choice the color | hidden text insert quote Convert selected text from transliteration to Cyrillic alphabet Insert spoiler

Code: *


Back1 2 3 4 5 6 7 Next